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Job ad: Available postdoc position on loxin variants at the section for metabolic genetics, University of Copenhagen
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Available postdoc position on loxin variants at the section for metabolic genetics, University of Copenhagen
Lectin-like oxidized low-density lipoprotein receptor (LOX-1), a type II transmembrane protein, is a scavenger receptor up regulated during vascular inflammation.
A soluble form of LOX-1 (sLox-1) results from proteolytic cleavage (by ADAM10 and ADAM17 proteases) of its extracellular domain that reflects total LOX-1 levels and represents a potential biomarker for cardiovascular (CV) risk.
Our hypothesis is that subjects with high sLox-1 levels will show a propensity for increased CVD whereas LOXIN mutations will confer reduced CVD risk. To date, association studies using either sLox-1 or LOXIN have not been conducted in large population cohorts.
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