Job ad: Available postdoc position on loxin variants at the section for metabolic genetics, University of Copenhagen

Region Syddanmark

Available postdoc position on loxin variants at the section for metabolic genetics, University of Copenhagen

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Lectin-like oxidized low-density lipoprotein receptor (LOX-1), a type II transmembrane protein, is a scavenger receptor up regulated during vascular inflammation.

A soluble form of LOX-1 (sLox-1) results from proteolytic cleavage (by ADAM10 and ADAM17 proteases) of its extracellular domain that reflects total LOX-1 levels and represents a potential biomarker for cardiovascular (CV) risk.

Our hypothesis is that subjects with high sLox-1 levels will show a propensity for increased CVD whereas LOXIN mutations will confer reduced CVD risk. To date, association studies using either sLox-1 or LOXIN have not been conducted in large population cohorts.